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May 2026

Comparative effectiveness of percutaneous needle electrolysis and shockwave therapy in subscapularis tendinopathy: a randomized clinical trial

Authors: Adrian Kuzdzal 1, Malgorzta Smoter 2, Gracjan Olaniszyn 3, 4, Bartlomiej Bogdanski 5, Tomasz Halski 6, Robert Trybulski 7, 8

Affiliations:

  1. Institute of Physiotherapy, Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, Rzeszow, Poland
  2. Department of Basic Physiotherapy, Gdansk University of Physical Education and Sport, Gdansk, Poland
  3. Medical Department Wojciech Korfanty, Upper Silesian Academy in Katowice, Katowice, Poland
  4. Olaniszyn Physiotherapy Centre, Raciborz, Poland
  5. Doctoral School of Gdansk University of Physical Education and Sport, Gdansk, Poland
  6. Faculty of Health Sciences, University of Opole, Opole, Poland
  7. Faculty of Medicine, Katowice Business University, Katowice, Poland
  8. Provita Zory Medical Center, Zory, Poland

Journal: Pain Management - May 2026 (DOI: 10.1080/17581869.2026.2669520)

Objectives: To evaluate whether adding ultrasound-guided percutaneous needle electrolysis (PNE) to extracorporeal shockwave therapy (ESWT) and therapeutic exercise improves short-term outcomes in adults with imaging-confirmed subscapularis tendinopathy.

Methods: This assessor-blinded, randomized, parallel-group clinical trial included 30 participants randomly allocated (1:1) to PNE+ESWT+exercise (n = 15) or ESWT+exercise (n = 15) for 8 weeks. Primary outcomes were pain (VAS), upper-limb disability (DASH), and tendon stiffness; secondary outcomes were pressure pain threshold, internal rotation range of motion and strength, cross-sectional area, tissue perfusion, Tenascin-C, and ultrasound tendon integrity findings.

Results: Compared with ESWT+exercise, PNE+ESWT+exercise produced significant improvements in tendon stiffness (between-group difference in change, −31.29 N/m [95% CI, −36.65 to −25.93]; interaction p < .001), DASH disability (−3.91 points [95% CI, −5.84 to −1.97]; p < .001), pressure pain threshold (10.01 kPa [95% CI, 9.07 to 10.94]; p < .001), internal rotation range of motion (5.29° [95% CI, 4.18 to 6.39]; p < .001), internal rotation strength (1.53 kgF [95% CI, 1.15 to 1.92]; p < .001), cross-sectional area (−0.99 mm2 [95% CI, −1.20 to −0.79]; p < .001), and Tenascin-C (19.90 pg/mL [95% CI, 7.63 to 32.17]; p = .002).

Conclusions: Adding PNE to ESWT, manual therapy, and exercise was associated with greater short-term improvements in upper-limb disability, tendon properties, and shoulder mechanical performance. Pain improved in both groups, without a between-group difference.

 

Keywords: tendinopathy, electrolysis, shockwave therapy, physical therapy modalities, randomized controlled trial

In this randomized clinical trial, adding ultrasound-guided PNE to ESWT, manual therapy, and exercise was associated with greater short-term improvements in upper-limb disability, tendon stiffness, pressure pain threshold, internal rotation range of motion, internal rotation strength, cross-sectional area, and Tenascin-C than ESWT, manual therapy, and exercise alone. Pain improved in both groups, without a between-group difference. These findings support PNE as a potentially useful adjunct within a multimodal physiotherapy program for subscapularis tendinopathy, but the results should be interpreted cautiously given the small sample, short-term follow-up, and absence of a sham control. Larger trials with longer follow-up are needed to confirm these findings and determine their durability.

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